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What is the best antipsychotic medication? Efficacy (symptom change) – the best performers were Clozapine, Amisulpride & Olanzapine, the worst performers were Asenapine, Lurasidone & Iloperidone. All cause discontinuation – the best performers were Amisulpride, Olanzapine & Clozapine, the worst performers were Lurasidone, Sertindole & Haloperidol.
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